The sleep–wake cycle is controlled by hypothalamic circuits. Signalling through these circuits is affected by the metabolic hormones leptin and ghrelin, connecting the sleep cycle with metabolism. On pages 362–370 of this issue, Adamantidis and de Lecea discuss the recent evidence showing that sleep and energy homeostasis are intertwined, highlighting the connectivity between neuronal circuits in the hypothalamus. The cover depicts a camping scene with people sleeping and eating under the same sky (hypothalamus), with the constellations representing the neurons activated in these circuits and the comets the hormones. Illustration by Yvonne Blanco.
Trends in Endocrinology and Metabolism contains polished and concise reviews, opinions, and discussions of topics at the cutting edge of the field. The articles incorporate clinical and research perspectives and differ from classical reviews with their focus on the more recent developments in each topic. The content is lively and accessible to a broad audience encompassing basic researchers, physician scientists, and clinical endocrinologists. Topics include physiological function of hormones and the tissues that secrete them, and the recent developments in the metabolism field, from lipid biology to diabetes/insulin resistance.
Commissioned Reviews and Opinion articles form the foundation of each monthly issue. Reviews objectively chronicle recent and important developments, while Opinion articles provide a forum for debate and hypothesis. The journal does consider unsolicited proposals.
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